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Migraine treatment- The new horizon in research work  




 Dr. Kundan Singh Dhillon*

  Dr. Jasmer Singh

  Dr. Jarnail Singh 

(For approval, comments and recommendation for the benefits of needy)


 *Contact: Residence:- Home # 803, Prem Nagar,

Ghumar Mandi, Ludhiana, Punjab, India

Phone No. 91-161-2770395


Migraine is almost as old as the human race itself. Malady IS more common in women than in men but its aetiology is not precisely known. The problem is so baffling that a "World Headache Committee" has been constituted to tackle it. Its varieties are as many as the individual patients. Pain during episode is so excruciating that only the suffer can appreciate it, no one else. Condition may start with yawning, nausea, vomition advancing to unbearable headache. There is no cardinal test for its diagnosis which is mostly made on the basis of subjective symptoms.


In the present study 12 patients of migraine headache were treated and the data collected on a proforma. Patients were divided into two groups, A and B. Each group consisted of 5 females and a male. Two female patients were kept as untreated controls which were treated later on. Laboratory grade zinc sulphate (Glaxo) was used to prepare stock solution by dissolving 15 gm. of salt in 1 litre of water thus giving 15 mg of salt per ml. of solution.


Group A: Each patient received 5 ml of zinc sulphate solution diluted to 60 ml with water once daily, 30 minutes after breakfast for 45 days.


Group B: Each patient received zinc sulphate solution as above. In addition received a capsule of vitamin A 5000 i.u. (trade mark of Nicholas Piramal Ltd. India) after 30 minutes of solution and vitamin B complexe (Becosule trade mark of Pfizer Ltd.) capsule after dinner for 10 days. The controls were administered 60 ml of aqua pura. Patients were routinely examined weekly for frequency and intensity of pain during attack, throbbing in temporal region nausea, phono and photophobia etc.

All patients responded favourably. Frequency and intensity of episode and nausea decreased, vomition stopped. There was decrease in frequency and intensity of phono and photophobia. Actually the poatients started feeling relieved 10 days after medication, intensity of pain decreased after 10 days and the process was progressive. In three weeks' time there was almost complete recovery in group B. In group A however the recovery was delayed 10-12 days. In all cases the recovery was complete and patients were no more apprehensive of episode and forgot "Migraine Walking".

After 45 days all patients recovered. Recovery in group B was 10-12 days earlier than in group A. All patients were observed for one year. There was no reoccurrence. No one came with a complaint even after that.

Traditionally migraine has been treated by palliative remedies like non-steroidal anti-inflammatory drugs, antihistaminics, beta blockers, ergot derivatives antemetics etc., but not with the desired success. Zinc sulphate gave a lasting effect as indicated by the present study.

Vascular disturbances of brain are responsible for migraine, there is constriction of brain blood vessels, resulting in cerebral ischaemia leading to spasm (Dalessio 1993). This is followed by vasodilation during the headache phase. Branches of external carotid artery especially the temporal, occipital and middle meningeal arteries are involved. Pulsatile form of headache changes to more constant dull headache (Dalessio, 1993). Godshy et al., (2002) have reported the involvement of calcium channels as well. Sicuteri et al., (1965) found an Increase in vascular permeability and dilation in cerebral vessels in migraine patients. All these conditions lead to local tissue changes like vessel oedema, scalp swelling and throbbing temporal arteries. Zinc sulphate provided triple pronged defence. It is an excellent antihypertensive agent and brought the BP to normal range (Dhillon et ai, unpublished data) thus controlled the throbbing. Being calcium channel blocker (Sarria et al., 1989) thus lowered the BP and over came the spasm. Zinc sulphate is also part of metaloenzymes needed for synthesis of DNA and RNA thus is a healing agent** and may have repaired the tissue damage to blood vessels and controlled tissue oedema and provided relief to tense nerves. Vitamin A is also needed for vessel epithelial repair. Synergistic effect of zinc sulphate and vitamin A might be responsible for earlier recovery in group B. Also vitamin B complexe is CNS tonic (Sarria et al., 1989). However, zinc sulphate alone also cured the patients though a bit later. There were no ill effects of zinc sulphate on patients' health at the present dose. Though Pories et al., (1967) used 220 mg zinc sulphate TID safely for wound healing. It would also mean that a higher dose may cut short the recovery period.

Dalessio D.J. (1993). Wolff's Headache and Other Pain. 6 Ed. New York: Oxford University Press.

Dhillon K.S. Singh J. and Layal J.S. (2006). Observations on antihypertensive effects of zinc sulphate in human subjects (unpublished data).

Godsby P.J., Lipton, R.B. and Ferrari, M.D. (2002) Migraine -Current understanding and treatment. N. Eng. J. Med. 346: 257-70.

**Pories W.J., Benzel, J.H., Red, e.G. and Stain H.A.V.W. (1967). Acceleration of wound healing in man with zinc sulphate given by mouth. Lanet  I : 121-24.

Sarria B., Cortizo J., Marti, Cabrera, M., Morcillo, E. and Esplugus J. (1989). Antagonism of calcium by zinc in guinae pig isolated tenia caeci and trachealis muscle. B. J. Pharmacol. 97 : 19-26.

Sicuteri F. (1966). Vasoactive substances in migraine. Headache.6: 109

* Dr. Kundan Singh Dhillon is one of the leading intellectuals and his profile is published in the book, ‘Leading Intellectuals of the World’ published by ‘The American Biographical Institute, Inc. United States of America’.

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